Over its original run and subsequent revival, the series underwent significant changes in setting, tone, and format. While the title suggests a single, contained escape, the narrative expanded far beyond prison walls, evolving into a sprawling saga of conspiracy, revenge, and espionage. Below is a comprehensive episode-by-season guide to Prison Break , including the 2017 revival.
| Season | Original Run | Number of Episodes | Primary Setting / Theme | | :--- | :--- | :--- | :--- | | | 2005–2006 | 22 | Fox River Prison (The Breakout) | | Season 2 | 2006–2007 | 22 | The American Manhunt | | Season 3 | 2007–2008 | 13 | Sona Prison (Panama) | | Season 4 | 2008–2009 | 22 | The Heist for Scylla | | The Final Break | 2009 (Movie) | 2 (Direct-to-DVD) | Conclusion of the original story | | Season 5 | 2017 | 9 | Yemen Prison (The Revival) |
88 episodes