Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse mucocutaneous manifestations. Nasal sores—mucosal ulcers or crusted lesions within the nasal vestibule—are a recognized but often underreported feature. They fall under the American College of Rheumatology (ACR) criteria for SLE (oral or nasal ulcers).
Nasal Sores in Systemic Lupus Erythematosus: Clinical Features and Diagnostic Significance
Lupus nasal ulcers show interface dermatitis, lymphocytic infiltration, basement membrane thickening, and direct immunofluorescence (positive lupus band test in lesional skin).
