Pc — Intra

1. Definition and Basic Concept Intraperitoneal chemotherapy (Intra-PC) is a locoregional cancer treatment method where chemotherapeutic drugs are delivered directly into the peritoneal cavity —the space within the abdomen that encloses organs like the stomach, liver, intestines, and ovaries.

| Category | Specific Complications | |----------|------------------------| | | Anastomotic leak, intra-abdominal abscess, bleeding, prolonged ileus, reoperation (10–20%). | | Chemo-related (local) | Chemical peritonitis, sclerosing encapsulating peritonitis (rare but severe bowel obstruction), delayed wound healing. | | Chemo-related (systemic) | Bone marrow suppression, renal toxicity (cisplatin requires sodium thiosulfate protection), neurotoxicity (paclitaxel), ototoxicity. | | HIPEC-specific | Hyperthermia-induced coagulopathy, electrolyte disturbances, hypotension, respiratory compromise (from increased intra-abdominal pressure). | | Catheter/Port-related | Infection, blockage, drug extravasation. | intra pc

For the right patient—good performance status, limited extraperitoneal disease, and a tumor biologically responsive to chemotherapy—Intra-PC can convert a uniformly fatal condition (peritoneal carcinomatosis) into a chronic or potentially curable disease. Ongoing innovations like PIPAC and targeted intraperitoneal agents promise to reduce invasiveness and broaden applicability. | | Chemo-related (local) | Chemical peritonitis, sclerosing

Intra-PC is not a replacement for systemic chemotherapy but an adjunct or alternative for a specific subset of patients with cancer confined to the abdominal cavity. Its success hinges on multidisciplinary selection, high-volume center care, and meticulous postoperative management. high-volume center care